Research Fellow in Liver Vascular Complications of Dengue Fever at University of Surrey

Post Type: Full Time, Fixed Term (3 years)

Closing Date: 23.59 hours BST on Sunday 06 August 2023

Reference: 034523

We are excited to advertise a postdoctoral position that will be the key research scientist in an exciting multidisciplinary project, which is a collaboration between the University of Surrey (Dr Paola Campagnolo) and The Pirbright Institute (Dr Kevin Maringer).

In this project, we aim at identifying the role of liver perivascular cells (stellate cells) in the vascular complications of dengue. Severe dengue is often characterised by haemorrhagic manifestations, leading to plasma and blood extravasation, and the liver is majorly affected by this disease. We have discovered that the circulating dengue protein NS1 inhibits the ability of perivascular cells (pericytes) to support the vascular barrier function (Cheung et al., 2020, MSphere). In this project, we will further investigate this mechanism in liver vasculature, utilising cutting-edge co-culture system and functional assays, combined with 3D multicellular organoids.

Dengue virus infection has been reported as one of the top-ten health threat by the WHO in 2020. With half of the world population at risk of infection mainly in low-mid income countries and over 500,000 individuals developing severe symptom, this project has the potential to deliver real life-changing impact by helping to reduce the risk of deathly complications. 

About you

We are looking for a positive individual with extensive experience in cell culture (vascular cells or liver cells, preferably) and confocal imaging – some knowledge of 3D cultures and vascular functional assay would also constitute an advantage. Competency in data analysis and scientific writing (as evidenced by authorship of peer-reviewed publications) is fundamental. We are looking for someone able to work and think independently as well as interact positively with colleagues and collaborators. Your PhD could be in Biological Sciences, Cardiovascular Sciences, Virology or related subjects. Interest in public engagement and website design would be a bonus. 

The successful applicant should be available to start no later than 1^st November 2023.

What we can offer

The University of Surrey is located on a beautiful, leafy campus in Guildford, just 30 miles from London and benefitting from excellent rail and road connections. In addition to your salary, you will receive pension contributions via the Universities Superannuation Scheme, a generous annual leave entitlement, relocation assistance where appropriate, an attractive research environment, and access to a variety of staff development opportunities as well as discounted membership in the Surrey Sports Park.

Further information

To apply, please submit a CV and cover letter detailing your experience and suitability for the role.

For more information and informal enquiries, contact Dr Paola Campagnolo (e-mail: p.campagnolo@surrey.ac.uk).

The University of Surrey is committed to providing an inclusive environment that offers equal opportunities for all.  We place great value on diversity and are seeking to increase the diversity within our community.  Therefore we particularly encourage applications from under-represented groups, such as people from Black, Asian and minority ethnic groups and people with disabilities.