Postdoctoral Research Associate at University of Dundee

We are recruiting for an exceptional individual to join us as a Postdoctoral Research Associate within our research team, to uncover the synaptic localisation and interactome of the neurodegenerative disease-associated protein,

TDP-43. This is a fixed-term appointment for 24 months, thanks to a recent Academy of Medical Sciences Springboard Award.

Working in the lab of Dr Chris Henstridge, you will use high-resolution imaging techniques to assess TDP-43 localisation at a subcellular level, in post-mortem human brain. There will be a particular focus on the synaptic and subsynaptic localisation and how this might change in Motor Neuron Disease (MND). You will also use molecular techniques to extract TDP-43 interacting proteins from synaptically-enriched preparations and apply mass- spectrometry protocols to identify these interactors. Working with collaborators in Ulm, Germany the PDRA will also assess changes in the TDP-43 interactome in human iPSC-derived neurons from healthy donors and ALS donors.

The Henstridge lab was established in 2019 and currently consists of two full-time PhD students and a Postdoc. This position is a great opportunity to join a small yet highly collaborative and ambitious research team. You will have the opportunity to drive an exciting and achievable project over 24 months and experience the exciting imaging and proteomic studies underway in the lab.

The University of Dundee enjoys an international reputation for excellence that attracts top-class students and academics from across the world – with over 140 countries represented in the University community. You will be based at Ninewells Hospital and Medical School, one of Europe’s largest teaching hospitals where the School of Medicine provides outstanding opportunities in medical education and training supported by world class research facilities.

Your priorities will include:

• Taking a lead role in establishing and driving the research project
• Staining,imaging,andanalysinghigh-resolutionmicroscopyimagesof human post-mortem bra! in
• Establishing co-IP protocols for extracting TDP-43 interactors
• Performing bioinformatic analyses of proteomics datasets
• Being closely involved in dissemination of the research work at scientific meetings and public engagement activities, by giving oral presentations, and for writing and resulting research papers for publication

Who we’re looking for:

• A primary degree in a relevant biological science
• A PhD in a relevant scientific area
• Experience of research techniques applicable to the project, including high-resolution imaging, molecular biology, and proteomics
• Evidence of working successfully in a collaborative research environment

The University of Dundee is a signatory of the Researcher Development Concordat and is committed to enhancing the research environment and culture. Engagement and support of activities which assist the researcher development agenda at the University is therefore essential.

For further information about this position please contact Dr. Chris Henstridge at c.henstridge@dundee.ac.uk.

To read some of the Henstridge group’s outputs please visit ?Christopher Henstridge – ?Google Scholar

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.