Development of host biomarker analysis methods for parallel determination of host response and bacterial infection in sepsis at University of Southampton

Start date:  25/09/2023

Project description:

There is unprecedented potential to learn and establish methodologies for the identification of host biomarkers from plasma generated within a diagnostic workflow, concurrently with the DNA sequencing of bacterial species present in the analysed samples. The potential host biomarkers encompassed in this investigation include, but are not limited to, CRP, procalcitonin, presepsin, IL-6, lipopolysaccharide-binding protein, as well as other relevant metabolic markers. These biomarkers serve as crucial indicators for determining the sepsis status of a patient more accurately/ rapidly. By integrating these diverse approaches, this study aims to improve the diagnostic accuracy and provide comprehensive insights into the septic state of individuals through the combined analysis of bacterial DNA sequencing and host biomarker profiling derived from plasma samples

The project sets out to diagnoses sepsis sooner and more accurately which in turn impact on early intervention of therapy and better outcome.This project will use novel and existing biomarkers to integrate to clinical scoring systems as well as DNA sequencing of bacteria which enhances knowledge about how patients with sepsis get manged more appropriately and could lead to future clinical trials.  It will become a crucial aspect of the NHS Long Term Plan and Genomic Medicine Service and our commitment to become one of the genomic centres of excellence for infection in the UK to harness genomic technology to improve the health of the population/ enhance epidemiological surveillance and early detection of infectious threats as part of a world-leading group in generating vast genomic data for infectious diseases. Working within trusted research environments, we now have the exciting opportunity to develop and optimise methods to integrate these biomarker and sequencing data to patients pathways.

Working within the NIHR Southampton Biomedical Research Centre, the project centred around translating cutting-edge diagnostic tools and technologies to improve patient outcomes. The University of Southampton and University Hospital Southampton NHS Foundation Trust boast a nationally leading infection team with a wide research profuile and links to UK wide and global researchers. The project will test and implement novel approaches in the diagnosis of sepsis in a real-world patient samples.

The successful candidate is likely to have the following qualifications:

• A 1^st or 2:1 degree in a relevant discipline and/or second degree with a related Masters.

Funding information:

Due to funding restrictions this position is only open to UK applicants. 

This PhD studentship is funded for 4 years by BRC and GenomeKey (Genomoic Lab Ltd). 

Amount of stipend £18,662.00 plus fees at UK residency rate only