[ad_1] Vacancy terms: Full time or job share, fixed term for two years Hours per week: 37.5 Advert closes midnight on: 08 Oct 2023 Abo
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Vacancy terms: Full time or job share, fixed term for two years
Hours per week: 37.5
Advert closes midnight on: 08 Oct 2023
About the role
We are looking for a talented and motivated individual to join the new NIHR Leicester Biomedical Research Centre (BRC) Environment Theme and the Department of Genetics and Genome Biology to investigate the importance of air pollution in promoting microbial-human interaction.
Our interdisciplinary research shows that air-borne particulate pollutants impact directly on bacteria to potentiate infection, irrespective of the effect of pollutants on the host. We found that physical interaction of bacteria with the particulate pollutant, black carbon, results in an unusual pattern of gene expression, increasing colonisation of abiotic and biotic surfaces, including the respiratory tract in a murine infection model, and alters antibiotic resistance. However, understanding of how air pollutants alter microbial interaction with the human respiratory tract is severely lacking.
The aim of this project is to increase understanding of the biological mechanisms involved in the relationship between air pollution, bacterial pathogens and respiratory tract health. This is an interdisciplinary post that involves close collaboration with microbiologists, environmental scientists and respiratory clinicians.
The NIHR Leicester BRC is a partnership between the University of Leicester, University Hospitals of Leicester NHS Trust, Loughborough University and the University Hospitals of Northamptonshire NHS Group. It has been funded £26.1 million from December 2022 to November 2027 to carry out pioneering research into medical advancements into illnesses linked to respiratory diseases, cardiovascular diseases, and type 2 diabetes, chronic kidney disease and the consequences of inactivity will continue to push boundaries of knowledge in clinical medicine. Three new speciality areas have joined the NIHR Leicester BRC for the first time: Personalised cancer prevention and treatment, Environment – looking at how the environment impacts on long term health conditions – and Using data to better understand multiple long term health conditions and factors specific to the health of ethnic minority populations. In addition, the respiratory speciality is joined by experts in infectious diseases.
Our overall purpose is to translate scientific breakthroughs in these areas into diagnostic tests, preventions and life-saving treatments for our patients. We do this by creating a collaborative workspace that allows scientists and clinicians to share their findings and deliver research that is relevant to both patients and the professionals who treat them.
About you
You will have a PhD in Microbiology/Immunology/Molecular Biology (awarded or submitted) as well as evidence of contribution to peer-reviewed journal papers. You will have extensive experience studying human-bacterial interaction. Your knowledge will also consist of molecular microbiology, and immunology. Alongside this, you will have experience of working with advanced imaging technology, ‘omics analysis, and human tissue culture.
To be successful in this role, you will need to have a proven ability of training and supervision of new members of the lab, including undergraduate and PhD students as well as evidence of research productivity.
Additional information
Informal enquiries are welcome and should be made to Dr Hayley King at hck6@leicester.ac.uk.
The University of Leicester has been changing the world, and changing people’s lives, for 100 years. When you join us, you’ll become part of a community of Citizens of Change, which includes not only our staff and our current students but also thousands of Leicester graduates around the world.
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