Harnessing the regenerative potential of the brain at University of Cambridge

We are looking for a highly motivated post-doctoral scientist to join the laboratory of Dr. Sumru Bayin at the Gurdon Institute, University of Cambridge. You will work in the Bayin Lab to explore the molecular mechanisms that regulate the regenerative potential of stem cells in the brain during development and in adulthood using various techniques including but not limited to single cell genomics, and in vivo and in vitro stem cell assays, organoid models and mouse genetics.

The Bayin Lab is interested in identifying the molecular mechanisms that regulate self-renewal, differentiation and plasticity of neural stem/progenitor populations during development and homeostasis, in order to discover how to stimulate repair of the brain upon injury. The cerebellum, which is a folded hindbrain structure that is important for skilled motor movements and higher order cognitive functions, has emerged as a powerful system to study the regenerative responses in the brain. We have previously shown that the cerebellum can recover from the loss of at least two types of neurons via distinct regenerative mechanisms (Wojcinski, Nature Neuroscience, 2017; Bayin, eLife, 2018; Bayin, Science Advances, 2021, Bayin and Joyner, Development, 2022). However, the full repertoire of molecular and cellular mechanisms that regulate neonatal cerebellar development and injury response remain to be studied.

Importantly, the regenerative potential of the neonatal cerebellum dramatically decreases once development ends, despite the presence of stem-like cells in the adult mouse cerebellum. This project involves using in vivo and in vitro approaches to identify mechanisms that control the developmental and regenerative responses of cerebellar progenitors in neonates and determine how it differs in adults in order to understand how we can facilitate efficient repair after injury to the brain. A variety of other projects on neural stem cell biology during brain development and pathologies are possible, depending on the candidate’s interest and background.

Applicants must have (or expect to obtain) a PhD (or equivalent) in biological sciences, preferably in cell, developmental biology or in genetics. A background and/or interest in bioinformatics is desired. Importantly, we are looking for a highly motivated and enthusiastic team member who is a critical thinker and can work independently, and have excellent communication skills with the ability to work collaboratively within and outside of the laboratory, and promote positive research culture within the laboratory. 

Our lab is funded by a Wellcome Career Development Award and the Royal Society and is a part of the vibrant research community at the University of Cambridge. Successful candidates will have access to career development activities and additional training opportunities offered by the School of Biological Sciences.

The salary range if appointed as a Research Associate is Grade 7 £36,024-£44,263 per annum, and the salary range if appointed as Research Assistant is Grade 5 £32,982 per annum with promotion to Research Associate on attainment of PhD. 

Fixed-term: The funds for this post are available until 30 June 2025 in the first instance.

Please quote reference PR38460 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.