Postdoctoral Research Fellow – the role of the nuclear periphery in genome integrity at University of Sussex

Contract: fixed term for 3 years

Reference: 20927

Closing date: 11 July 2023.

Applications must be received by midnight of the closing date.

Expected Interview date: To be confirmed

Expected start date: August 2023 / As soon as possible.

The School of Life Sciences at the University of Sussex is at the forefront of research in the UK. In the recent Research Excellence Framework assessment (REF 2021), 100% of our Impact cases in Biological Sciences and Chemistry were rated as world-leading or internationally excellent. The School has received substantial recent University investment and is embarking on an exciting and extensive, muti-million pound refurbishment and improvement project.

Based in the School of Life Sciences, the Genome Damage and Stability Centre  (http://www.sussex.ac.uk/gdsc/), is an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability and its relationship to disease. We provide a stimulating and supportive environment and our expertise covers a range of experimental systems.

Motivated applicants are invited to apply for a UKRI-funded postdoctoral position to study the role of the nuclear periphery in genome and epigenome integrity. We will investigate whether DNA damage-induced epigenetics changes at Lamina Associated domains (LADs) are fully restored after DNA repair and decipher the interplay between genetic and epigenetic restoration at LADs. We will determine the long-term consequences of genetic and epigenetic scars in cell fitness and senescence. For visualization and mapping of breaks and epigenetic changes high end microscopy, proximity labeling, proteomics and NGS approaches will be used. Expertise in any of the above will be positively considered but not absolutely required.  

Required qualifications for this position:

• First author publication(s) in a reputable journal.
• Highly motivated to develop new cutting end approaches.
• Commitment to work in a highly competitive field.
• Ability to independently drive a research project and analyse data.
• Fluent in written /spoken English and writing scientific reports/papers.

Potential candidates are strongly encouraged to contact Prof. Evi Soutoglou before applying. E-mail: E.Soutoglou@sussex.ac.uk;

The School of Life Sciences is committed to increasing the diversity of its staff and providing an inclusive working environment. The School currently holds an Athena SWAN Silver Award, has developed a Race Equity Action Plan and hosts an active Equality, Diversity and Inclusion working group.

Applications are particularly welcomed from Black and minority ethnic candidates, and women, trans and non-binary candidates, who are under-represented in the School of Life Sciences.

Applications to posts from candidates who wish to work part-time or as job-sharers are welcome.

The University offers various schemes to provide real benefits to parents, these can be found at Family Friendly Policies

Applications should be accompanied by a full CV, a statement of research interests and aspirations (not more than 4 pages), and the names of three academic referees.

“Please note that this position may be subject to ATAS clearance if you require visa sponsorship.”

For full details and how to apply see our vacancies page

The University of Sussex values the diversity of its staff and students and we welcome applicants from all backgrounds.

Please note: The University requires that work undertaken for the University is performed from the UK.