[ad_1] Beatson lab: Mitochondrial Oncogenetics Dr Payam Gammage Project Title: The impact of mitochondrial DNA mutation on tumour mic
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Beatson lab: Mitochondrial Oncogenetics
Dr Payam Gammage
Project Title: The impact of mitochondrial DNA mutation on tumour microenvironments
Contract term: Fixed up to 6 years, subject to successful review at Year 3
About us
The CRUK Beatson Institute where the lab is based is a world leading cancer research institute, situated in the vibrant city of Glasgow in Scotland and hosting approximately 60 postdoctoral researcher scientists at any one time. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis.
Project outline
The majority of cancers bear mutations of the mitochondrial genome. Our recent work has identified recurrence and selection of these mutations in tumours (Gorelick et al., 2021, Nature Metabolism) and forthcoming papers from our lab show that a key impact of these mutations is altered tumour metabolism, driving divergent tumour microenvironments that mediate susceptibility to treatment (Mahmood et al., 2023, biorXiv). In the Mitochondrial Oncogenetics Lab at CRUK BI, we have developed and applied advanced mitochondrial genome engineering techniques to create models of mitochondrial mutant cancer that we study in a variety of contexts.
We aim to develop a broad understanding of the impact mtDNA mutations exert within and between tissue lineages, and this project will define the impact of recurrent mtDNA mutations on cancer metabolism, tumour growth and the immune microenvironment.
The successful applicant will be highly enthusiastic, driven to succeed and already have or soon be completing a PhD in mitochondrial biology, cancer or immunology. Experience of any of the following: single cell approaches, cancer genomics, in vivo cancer modelling and/or quantitative approaches to metabolic science are desirable but not essential.
Gorelick AN, et al., 2021, Respiratory complex and tissue lineage drive recurrent mutations in tumor mtDNA. Nature Metabolism. 3:558-570.
Kim M, et al., 2022, Mitochondrial DNA is a major source of driver mutations in cancer. Trends in Cancer. 8:1046-1059.
Mahmood et al., 2023, Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade. biorXiv. https://doi.org/10.1101/2023.03.21.533091
For informal enquiries, please email payam.gammage@glasgow.ac.uk
All applications must be made via the ‘Apply’ button above
Closing Date: Friday 15th September 2023 but we may contact promising candidates on a rolling basis, so please apply as soon as you are ready.
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